Will Ferrell plans to remake Manimal. Yes, Manimal.
I imagine a fairly comedic version, where our hero turns into animals at inconvenient times with little control. Something a bit Night Of The Museum perhaps.
I suggested this years ago (as a result of a dare on RPGnet) to be played semi-straight in an Angel kind of way. (One correction made since - Stan Winston Studios to do the practical effects, and give them more than three hours for each!) If you can do a fairly serious urban fantasy series of Teen Wolf, why not?
Got any other series setups lying around spare?