Agents Of S.H.I.E.L.D. does something different, even to the title card, as we see what happened to Simmons in those ominous blue shots in 4,722 Hours. As well as being steeped in references (NASA timing and names, and I think that Astronaut may be Impossible) it really runs with a solo premise and guest appearance.
Since I started with solo gamebooks, the one-on-one session never seemed like a particularly odd idea to me. I will note previously stated warnings about a single player tearing through plot at great speed due to lack of debates and distractions and multiple player turns in combat and the like. The time will pass... maybe not like 4,722 hours in one, but pretty fast.