Vampyr, the new console and PC game from Dontnod, drops the player into a secret world of monsters hiding in 1918 London, as a doctor infected while trying to help with the Spanish Flu epidemic. There are other vampires out there (of various types) as well as hunters, and plenty of mortals, who are individualised.
For those who care about games about vampires, the most interesting point raised by this AV Club review is the feeding mechanic - drinking blood from and killing the named NPCs brings major XP and power boosts. And the more you know them, and the healthier they are - which as a doctor you can affect - the bigger the benefit. In Darkness terms, it’s nudging you to eat contacts and allies. You can go without but the game will be more difficult, though apparently not impossible.